OK, the general rule of thumb is to use "effect" as a noun, and "affect" as a verb... If you're just looking for a simple answer, there it is, you're done.
But: there are transitive verb ("t.v.") forms of each, and for a long time I wasn't terribly clear (probably an understatement) on the distinctions between those two.
Finally, though, with a little bit of research, I've figured it out. Put simply, "to effect" is basically synonymous with "to bring about" (or, a little more roughly, "to create"). "To affect" is basically synonymous with "to influence" (or "to change"). Thanks to the following pages for helping me clar this up, but I thought I'd make a record of my findings here, just in case those pages go away, or I forget, or whatever:
I hope I've effected (created) a page which can positively affect (influence) your understanding of this distinction. :-)
P.S. -- I was thinking about this just a bit more, shortly after writing the above, and I decided that it seems to me that it might just be the case that one effective definition of the transitive verb "to affect [something]" would be "to effect an effect [on that something]". OK, I'm getting silly with this now... 'nuff said.
Err, but really there are actually 3 forms of affect, and 2 of effect. Here's a summary (over-simplified), for easy reference:
Noun | Verb | Transitive Verb | |
---|---|---|---|
Affect | an Emotion | to tend toward or feign | To influence |
Effect | A change, impression, sign/appearance, or ability to influence | [N/A] | To bring about |